NGHIÊN CỨU BỘ MÔN BÀO CHẾ

HƯỚNG NGHIÊN CỨU

• Chiết xuất, tiêu chuẩn hóa nguyên liệu làm thuốc có nguồn gốc từ dược liệu và ứng dụng phát triển các dạng sản phẩm bảo vệ sức khỏe, các chế phẩm thuốc dược liệu.
• Cải thiện độ tan và sinh khả dụng của dược chất với các kỹ thuật như tạo hệ phân tán rắn, tạo phức bao, hệ vi tự nhũ, hệ phân tán nano, micro, liposome
• Cải thiện độ hòa tan, độ ổn định các thuốc generic, thuốc phối hợp liều cố định (fixed dose combination)
• Nghiên cứu các hệ phân phối thuốc, các dạng bào chế mới: Thuốc viên (nén, nang) phóng thích kéo dài; thuốc (viên, màng film) rã nhanh, tan trong miệng; thuốc dán hấp thu qua da; thuốc nổi trong dạ dày (viên nén, cốm, gel in situ; các dạng bào chế in situ (gel, thuốc nhỏ mắt).
• Đánh giá sinh khả dụng và tương đương sinh học
• Dược mỹ phẩm và thực phẩm chức năng
• Pha chế theo đơn tại bệnh viện  

KẾT QUẢ NGHIÊN CỨU

Các công bố quốc tế (Cập nhật đến ngày 31/12/2023)

1. Van Hy Triet, Tran Van Thanh, Ha Manh Tuan, Vu Quang Huy, Model of implementing proficiency testing in Vietnam, a developing country, 2023, Practical Laboratory Medicine 37, pp. e00339.
2. Nguyet A.T. Nguyen, Tam M. Le, Hai T. Nguyen, Khanh H.T. Pham, Hieu P.C. Truong, Phương D. Pham, Manh H. Tran, Method development for simultaneous quantification of polyphenol compounds in artichoke (Cynara scolymus L) leaf dry extracts by UPLC-PDA, Tropical Journal of Natural Product Research (2023), 7(9): 3995-4002.
3. Targeting Olokizumab-Interleukin 6 interaction interface to discover novel IL-6 inhibitors, Que-Huong Tran, Hoang-Nhi Cao, Dac-Nhan Nguyen, Thi-Thuy-Nga Tran, Minh-Tri Le, Quoc- Thai Nguyen, Van-Thanh Tran, Viet-Hung Tran, Khac-Minh Thai, 2023, Journal of Biomolecular Structure and Dynamics 41(23), pp. 14003-14015.
4. Nhu Thi Quynh Thai, Huy Nguyen Manh, Thanh Van Tran, Anh Tuan Le, Formulation of chewing gum containing Lactobacillus brevis NB10, 2022, MedPharmRes 7 (2), pp.13-24.
5. Manh Hung Tran, Duc Hanh Nguyen, Thi Hong Van Le, Huynh Van Thi Nguyen, Ngoc Tram Thi Nguyen, Phuoc Long Nguyen, Tan Khanh Nguyen, Thanh Duy Le. α-Glucosidase Inhibitory Activity and Quantitative Contribution of Phenolic Compounds from Vietnamese Aquilaria crassna Leaves. Natural Product communications 2022; 17(3): 1–10
6. Nguyen Anh Khoa Huynh, Thi Hong Tuoi Do, Xuan Loc Le, Truc Thanh Ngoc Huynh, Duc Hanh Nguyen, Ngoc Khue Tran, Cao Thuy Ha Lan Tran, Dai Hai Nguyen, Cong Tri Truong. Development of softgel capsules containing cyclosporine a encapsulated pine essential oil based self-microemulsifying drug delivery system. Journal of Drug Delivery Science and Technology 2022; 68:103115.
7. Van-Thanh Tran, Viet-Hung Tran, Dac-Nhan Nguyen, Tran-Giang-Son Do, Thanh-Phuong Vo, Thi-Thao-Nhung Nguyen, Phuong Nguyen Hoai Huynh, Khac-Minh Thai, The Effects of One-Point Mutation on the New Delhi Metallo Beta-Lactamase-1 Resistance toward Carbapenem Antibiotics and β-Lactamase Inhibitors: An In Silico Systematic Approach, 2022, International Journal of Molecular Sciences, 23 (24), pp. 16083.
8. Thanh-Hoa Vo, Chia-Ching Liaw, Yu-Chi Lin, Duc Hanh Nguyen, Thi Tuyet Nhung Nguyen, Ching-Kuo Lee, Yao-Haur Kuo. Quantification and optimization of ethanolic extract containing the bioactive flavonoids from Millettia pulchra radix. Molecules 2021; 26(12), 3641.
9. Huynh Tran Quoc Dung, Pham Ngoc Thac, Nguyen Ngoc Thach, Nguyen Phuong Nam, Nguyen Duc Hanh. Simultaneous quantification of eurycomanone, epimedin C and icariin in film coated tablets containing Radix Eurycomae longifoliae extract and Herba Epimedii extract using HPLC – DAD. Pharmacia 2021; 68(2):365–373.
10. Quang Huy Vu, Hy Triet Van, Van Thanh Tran, Thi Diem Phuc Huynh, Van Chinh Nguyen, Dinh Thanh Le, Development of a robust blood smear preparation procedure for external quaility assessment, 2021, Practical Laboratory Medicine, 27, pp. e00253.
11. Nguyen Duc Hanh, Le Van Thinh, Do Quang Duong. Development and evaluation of neem gel formulation using gum karaya as gelling agent. Research J Pharm and Tech 2020;13(4):1861-1866.
12. Nguyen Duc Hanh, Phan Hoang Doan Phuong. Formulation of binary microemulsion of quercetin and curcumin. Pharmaceutical Journal 2020; 60(525):15-20.
13. Hoang Thuy Linh, Trinh Xuan Tung, Trinh Huu Tung, Vo Quoc Bao, Le Thi Minh Hong, Pham Ngoc Thach, Nguyen Minh Ngoc, Luu Thanh Binh, Phan Trong Lan, Hoang Quoc Cuong, Nguyen Duc Hai, Nguyen Duy Long, Nguyen Thi Thu Phuong, Van Thi Thuy Linh, Pham Thi Mai Anh, Nguyen Thien Hai, Le Quan Nghiem, Nguyen Duc Tuan, Risk of Microbiological Contamination when Preparing Total Parenteral Nutrition for Pediatric Patients: A Pilot Study at a Regional Hospital in Southern Vietnam. Systematic Reviews in Pharmacy, (2020), Vol.11, Issue 11 (2), 1-5
14. Hoang Thuy Linh, Trinh Xuan Tung, Trinh Huu Tung, Vo Quoc Bao, Le Thi Minh Hong, Pham Ngoc Thach, Nguyen Minh Ngoc, Luu Thanh Binh, Phan Trong Lan, Hoang Quoc Cuong, Nguyen Duc Hai, Nguyen Duy Long, Nguyen Thi Thu Phuong, Van Thi Thuy Linh, Pham Thi Mai Anh, Nguyen Thien Hai, Le Quan Nghiem, Nguyen Duc Tuan, Parenteral Nutrition Preparation Procedure: A Hazard Analysis and Critical Control Points Approach at a Pediatric Hospital in Vietnam, Systematic Reviews in Pharmacy, 2020, Vol.11, Issue 1, 159-164.
15. Le Van Thinh, Nguyen Duc Hanh. Development of an HPLC procedure for simultaneous determination of rutin and isoquercitrin in the cosmetic jels prepared from Neem (Azadirachta indica A. Juss., Meliaceae). Pharmaceutical Journal, 2019; 514(59): 35-40
16. Tran Thanh Tam, Nguyen Duc Hanh, Nguyen Duc Tuan. An HPLC method for simultaneous determination of geniposide and pinoresinol diglucoside in the binary compound tablets of Fructus Gardeniae and Cortex Eucommiae for blood hypetension. Pharmaceutical Journal 2019; 514(59): 24-30
17. Tran Thi Thu Van, Nguyen Duc Hanh, Do Quang Duong, Nguyen Minh Duc. Optimization of Vietnamese Ginseng extraction conditions. Ho Chi Minh City Journal of Medicine 2019; 23(2):242-248.
18. Tuong N G Nguyen, Van-Thanh Tran, Wei Duan, Phuong H L Tran, Thao T D Tran, Nanoprecipitation for Poorly Water-Soluble Drugs, 2018, Current Drug Metabolism, 18 (11), pp.1000-1015.
19. Minh Nguyet Pham, Toi Van Vo, Van-Thanh Tran, Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, Microemulsion-based mucoadhesive buccal wafers: wafer formation and in vitro release profiles, 2017, AAPS PharmSciTech, 18, pp.2727-2736.
20. Vuong Duy Ngo, Thinh Duc Luu, Toi Van Vo, Van-Thanh Tran, Wei Duan, Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, an investigation of effects of modification processes on physical properties and mechanism of drug release for sustaining drug release from modified rice, 2016, Materials Science and Engineering: C 67 (1), pp. 1-7.
21. Tran TT, Tran PH, Nguyen KT, Tran VT., Nanoprecipitation: Preparation and application in the field of pharmacy, 2016, Current Pharmaceutical Design, 22(20), pp. 2997-3006.
22. Hai Van Ngo, Phuc Kien Nguyen, Toi Van Vo, Wei Duan, Van-Thanh Tran, Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, Hydrophilic-hydrophobic polymer blend for modulation of crystalline changes and molecular interactions in solid dispersion, 2016, International Journal of Pharmaceutics, 513 (1-2), pp. 148-152.
23. Violet Fabien, Le Minh-Quan, Sergent Michelle, Bastiat Guillaume, Tran Van-Thanh, Venier-Julienne Marie-Claire, Development of prilling process for biodegradable microspheres through experimental designs, 2016, International Journal of Pharmaceutics, 498 (1-2), pp. 96-109
24. Nguyen Duc Hanh, Ampol Mitrevej. Development and evaluation of phyllanthin-loaded nanostructured lipid carriers. Ho Chi Minh city Journal of Medicine 2016; 20(2)278-284.
25. Nguyen Duc Hanh, Ampol Mitrevej, Korbtham Sathirakul, Penchom Peungvicha, Nuttanan Sinchaipanid. Development of phyllanthin-loaded self-microemulsifying drug delivery system for oral bioavailability enhancement. Drug Dev Ind Pharm 2015; 41(2):207-217.
26. Dinh-Duy Pham, Elias Fattal, Nicolas Tsapis (2015). "Pulmonary drug delivery systems for tuberculosis treatment." International Journal of Pharmaceutics 478(2): p. 517-529.
27. Dinh-Duy Pham, Nicolas Grégoire, William Couet, Claire Gueutin, Elias Fattal, Nicolas Tsapis (2015). "Pulmonary delivery of pyrazinamide-loaded large porous particles." European Journal of Pharmaceutics and Biopharmaceutics 94: p. 241-250.
28. Dinh-Duy Pham, Elias Fattal, Nicolas Tsapis (2015). "Pyrazinamide-loaded poly(lactide-co-glycolide) nanoparticles: Optimization by experimental design." Journal of Drug Delivery Science and Technology 30: p.384-390.
29. Khac-Minh Thai, Nghia-Tin Huynh, Trieu-Du Ngo, Thanh-Tan Mai, Thien-Hai Nguyen, and Thanh-Dao Tran, Three and four-class classification models for P-glycoprotein inhibitors using the counter propagation neural networks, SAR and QSAR in Environmental Research, 2015, Vol. 26, issue 2, 139-163.
30. Khac-Minh Thai, Trieu-Du Ngo, Thien-Vy Phan, Thanh-Dao Tran, Ngoc-Vinh Nguyen, Thien-Hai Nguyen, and Minh-Tri Le, Virtual Screening for Novel Staphylococcus Aureus NorA Efflux Pump Inhibitors from Natural Products, Medicinal Chemistry, 2015, Vol. 11, issue 2, 135-155. 
31. Tuong Ngoc-Gia Nguyen, Phuong Ha-Lien Tran, Thanh Van Tran, Toi Van Vo, Thao Truong-DinhTran, Development of a modified - solid dispersion in an uncommon approach of melting method facilitating properties of a swellable polymer to enhance drug dissolution, 2015, International Journal of Pharmaceutics, 484 (1-2), pp. 228-234.
32. Nguyen Duc Hanh, Nuttanan Sinchaipanid, Ampol Mitrevej. Physicochemical characterization of phyllanthin from Phyllanthus amarus Schum. et. Thonn. Drug Dev Ind Pharm 2014; 40:793-802.
33. Nguyen Duc Hanh, Nuttanan Sinchaipanid, Ampol Mitrevej. In vitro intestinal transport of phyllanthin across Caco-2 cell monolayer. J Drug Deliv Sci Tec 2013;2 3: 207-214.
34. Dinh-Duy Pham, Elias Fattal, NourEddine Ghermani, Nicolas Guiblin, Nicolas Tsapis (2013), Formulation of pyrazinamide-loaded large porous particles for the pulmonary route: Avoiding crystal growth using excipients. International Journal of Pharmaceutics, 454(2): p. 668-677.
35. Marie Morille, Tran Van-Thanh, Xavier Garric, Jérôme Cayon, Jean Coudane, Danièle Noël, Marie-Claire Venier-Julienne, Claudia N Montero-Menei, New PLGA-P188-PLGA matrix enhances TGF-β3 release from pharmacologically active microcarriers and promotes chondrogenesis of mesenchymal stem cells, 2013, Journal of Controlled Release, 170 (1), pp. 99-110.
36. Padois K, Bertholle V, Pirot F, HuynhTT, Rossi A, Colombo P, Falson F, Sonvico F. (2012), Chlorhexidine salt-loaded polyurethane orthodontic chains: in vitro release and antibacterial activity studies. AAPS PharmSciTech. 2012 Dec;13(4):1446-50.
37. Van-Thanh Tran, Jean-Pierre Karam, Xavier Garric, Jean Coudane, Jean-Pierre Benoît, Claudia N. Montero-Menei, Marie-Claire Venier-Julienne, Protein-loaded PLGA–PEG–PLGA microspheres: A tool for cell therapy, 2012, European Journal of Pharmaceutical Sciences, 45 (1-2), pp.128-137.
38. Van-Thanh Tran, Jean-Pierre Benoît, Marie-Claire Venier-Julienne, Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy? 2011, International Journal of Pharmaceutics, 407 (1-2), pp.1-11.
39. Huynh TT, Padois K, Sonvico F, Rossi A, Zani F, Pirot F, Doury J, Falson F. (2010), Characterization of a polyurethane-based controlled release system for local delivery of chlorhexidine diacetate. Eur J Pharm Biopharm, 74(2):255-64.
40. A. Paillard-Giteau, V.T. Tran, O. Thomas, X. Garric, J. Coudane, S. Marchal, I. Chourpa, J.P. Benoît, C.N. Montero-Menei, M.C. Venier-Julienne, Effect of various additives and polymers on lysozyme release from PLGA microspheres prepared by an s/o/w emulsion technique, 2010. European Journal of Pharmaceutics and Biopharmaceutics, 75(2), pp.128-136.
41. Atrux-Tallau N, Huynh NT, Gardette L, Pailler-Mattéi C, Zahouani H, Viviant E, Hirsch H, Marek H, Falson F, Pirot F. (2008), Effects of physical and chemical treatments upon biophysical properties and micro-relief of human skin. Arch Dermatol Res. 2008 Jun;300(5):243-51.
42. Katsuaki Ito, Hai Thien Nguyen, Yukio Kato, Tomohiko Wakayama, Yoshiyuki Kubo, Shoichi Iseki, Akira Tsuji, P-Glycoprotein (Abcb1) is involved in absorptive drug transport in skin, Journal of Controlled Release, Vol. 131, Issue 3, 12 November 2008, Pages 198-204.
43. Nguyen Thien Hai, Ju-Young Kim, Eun-Seok Park and Sang-Cheol Chi, Formulation and Biopharmaceutical Evaluation of Transdermal Patch Containing Benztropine, International Journal of Pharmaceutics, Vol. 357, Issues 1-2, 5 June 2008, Pages 55-60.
44. Katsuaki Ito, Hiroyuki Tsuji, Nguyen Thien Hai, Yoshiyuki Kubo, Yukio Kato, Akira Tsuji, Involvement of Organic Anion Transport System in Transdermal Absorption of Flurbiprofen, Journal of Controlled Release, Vol. 124, Issues 1-2, 4 December 2007, Pages 60-68.
45. In-Ja Ko, Nguyen Thien Hai, Sang-Cheol Chi, Bioequivalence of Hanmi fexofenadine hydrochloride tablet 120 mg, Kor. J. Clin. Pharm., Vol. 16, No 1. 2006, Pages 34-39.

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